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J Rheumatol — Rheumatology Oxford — CrossRef. Rhumatologie — PubMed. Lupus — PubMed CrossRef. Zurück zum Zitat Churchill FC, Mount DL, Schwartz IK Determination of chloroquine and its major metabolite in blood using perfluoroacylation followed by fused-silica capillary gas chromatography with nitrogen-sensitive detection. Evaluation of anti-osteoarthritic effects of selected antirheumatic drugs administered systemically.

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Inhibition of proteolytic enzymes in connective tissue by chloroquine resorchin and related antimalarial antirheumatic drugs. J Org Chem — CrossRef.

A follow-up study. Agents Actions Suppl — PubMed. Rheumatology — PubMed CrossRef.

Trials Harvey Lect —87 PubMed. Electrophoresis — PubMed CrossRef. Bull Rheum Dis — PubMed. Zurück zum Zitat Dubois EL Antimalarials in the management of discoid and systemic lupus erythematosus. Focus on recent advancements. Zurück zum Zitat Easterbrook M Is corneal disposition of anti-malarials any indication of retinal toxicity? Can J Opthal — Easterbrook M Is corneal disposition of anti-malarials any indication of retinal toxicity?

Can J Opthal — Zurück zum Zitat Easterbrook M Screening for antimalarial toxicity: current concepts. Can J Ophthalmol. Circulation — PubMed CrossRef.

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Zurück zum Zitat Emami J, Pasutto FM, Jamali F Effect of experimental diabetes mellitus and arthritis on the pharmacokinetics of hydroxychloroquine enantiomers in rats. Marcel Dekker, New York, pp — Immunology — Zurück zum Zitat Fosdyke DR Evidence for a relationship between chloroquine and complement from studies with lymphocyte mitogens: possible implications for the mechanism of chloroquine in disease.

Can J Microbiol — CrossRef Fosdyke DR Evidence for a relationship between chloroquine and complement from studies with lymphocyte mitogens: possible implications for the mechanism of chloroquine in disease. Can J Microbiol — CrossRef. Zurück zum Zitat Fox R Anti-malarial drugs: possible mechanisms of action in autoimmune disease and prospects for drug development.

Zurück zum Zitat Furst DE Pharmacokinetics of hydroxychloroquine and chloroquine during treatment of rheumatic diseases. Drugs — PubMed CrossRef. Arch Fr Pediatr — PubMed. Pharmacogenomics — PubMed CrossRef. Zurück zum Zitat Ginsburg H, Geary TG Current concepts and new ideas on the mechanism of action of quinoline-containing antimalarials.

Zurück zum Zitat Glaumann H, Ahlberg J, Berkenstam A Rapid isolation of rat liver secondary lysosomes—autophagic vacuoles—following chloroquine administration.

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Exp Cell Res — CrossRef. Blood — PubMed. Comparison with other antiarthritic drugs. Zurück zum Zitat Gräbner R, Meerbach W Imipramine and chloroquine induce alterations in phospholipid content of rat lung.


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Exp Path — CrossRef. Zurück zum Zitat Grierson DJ Hydroxychloroquine and visual screening in a rheumatology outpatient clinic. Zurück zum Zitat Gupta JD, Gruca M, Ablett W Effect of other drugs and chemicals on the degradation of aspirin in vitro: possible extrapolation to in vivo metabolism of aspirin. Tropenmed Parasitol — PubMed. Optometry —94 PubMed CrossRef. Zurück zum Zitat Hedin U, Thyberg J Receptor-mediated endocytosis of immunoglobulin-coated colloidal gold particles in cultured mouse peritoneal macrophages.

Chloroquine and monensin inhibit transfer of the ligand from endocytic vesicles to lysosomes. Eur J Cell Biology — Hedin U, Thyberg J Receptor-mediated endocytosis of immunoglobulin-coated colloidal gold particles in cultured mouse peritoneal macrophages. Eur J Cell Biology — Lupus —15 PubMed CrossRef.

Lancet — PubMed CrossRef. Nature —52 PubMed CrossRef. Scan J Immunol — CrossRef. The effects of second-line antirheumatic drugs and cytotoxic agents on the histopathological changes. Zurück zum Zitat Hurst NP, French JK, Gorjatsschko L, Betts WH Studies on the mechanism of inhibition of chemotactic tripeptide stimulated human neutrophil polymorphonuclear leucocyte superoxide production by chloroquine and hydroxychloroquine.

J Rheumatol —27 PubMed. Zurück zum Zitat Ignarro LJ Dissimilar effects of anti-inflammatory drugs on stability of lysosomes from peritoneal and circulating leukocytes and liver. Biochem Pharmacol — PubMedCrossRef Ignarro LJ Dissimilar effects of anti-inflammatory drugs on stability of lysosomes from peritoneal and circulating leukocytes and liver.

Zurück zum Zitat Ignarro LJ Release of neutral protease and beta-glucuronidase from human neutrophils in the presence of cartilage treated with various immunologic reactants. J Immunol — PubMed Ignarro LJ Release of neutral protease and beta-glucuronidase from human neutrophils in the presence of cartilage treated with various immunologic reactants. Zurück zum Zitat Ignarro LJ, Colombo C Enzyme release from guinea-pig polymorphonuclear leucocyte lysosomes inhibited in vitro by anti-inflammatory drugs.

Zurück zum Zitat Iredale J, Fieger H, Wainer IW Determination of the stereoisomers of hydroxychloroquine and its major metabolites in plasma and urine following a single oral administration of racemic hydroxychloroquine. Semin Arthritis Rheum —81 PubMedCrossRef Iredale J, Fieger H, Wainer IW Determination of the stereoisomers of hydroxychloroquine and its major metabolites in plasma and urine following a single oral administration of racemic hydroxychloroquine.

Zurück zum Zitat Jokar M et al. Scand J Rheumatol —38 PubMed. Clin Res Clin Exp Rheumatol — Zurück zum Zitat Kamal MA, Jusko WJ Interactions of prednisolone and other immunosuppressants used in dual treatment of systemic lupus erythematosus in lymphocyte proliferation assays. Transfusion —17 PubMed CrossRef.

Zurück zum Zitat Katz SJ, Russell AS Re-evaluation of antimalarials in treating rheumatic diseases: re-appreciation and insights into new mechanisms of action. Zurück zum Zitat Kingsbury SR et al. Zurück zum Zitat Klinefelter HF, Achurra A Effect of gold salts and antimalarials on the rheumatoid factor in rheumatoid arthritis. J Biol Chem — PubMed. Arzneim Forsch — Adv Inflamm Res — Biochemistry — CrossRef.

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Zurück zum Zitat Kull FC Jr, Besterman JM Drug-induced alterations of tumour necrosis factor-mediated cytotoxicity: discrimination of early versus late stage action. A clinical study with determination of serum concentrations of chloroquine and hydroxychloroquine. Zurück zum Zitat Leoni A Gli effetti della chlorochina sulla riposte eritematosa al fenolo nei portatori di eritematode cronico. Minerva Derm — PubMed Leoni A Gli effetti della chlorochina sulla riposte eritematosa al fenolo nei portatori di eritematode cronico.

Minerva Derm — PubMed. In: Orme M ed Anti-rheumatic drugs. Pergamon Press, New York, pp — Acta Univ Carol Med Praha — Zurück zum Zitat Lowe JS, Turner EH The effect of adjuvant arthritis and drugs on the ability of rat plasma to inhibit the triton X induced lysis of rabbit polymorphonuclear leucocyte granules. Zurück zum Zitat Lullmann-Rauch R, Pods R, von Witzendorff B The antimalarials quinacrine and chloroquine induce weak lysosomal storage of sulphated glycosaminoglycans in cell culture and in vivo. Toxicology —37 PubMedCrossRef Lullmann-Rauch R, Pods R, von Witzendorff B The antimalarials quinacrine and chloroquine induce weak lysosomal storage of sulphated glycosaminoglycans in cell culture and in vivo.

Toxicology —37 PubMed CrossRef. Zurück zum Zitat Mackenzie AH c Dose refinements in long-term therapy of rheumatoid arthritis with antimalarials. Prostaglandins — PubMed CrossRef. Ophthalmology — PubMed CrossRef. Zurück zum Zitat Mary CF, Legros J Experimental study of ocular effects of hydroxychloroquine in the rat: influence of oxidiser status.

Br J Clin Pract 41 Suppl 52 — Treatment with combined cyclophosphamide, azathioprine, and hydroxychloroquine. Springer, Berlin, pp 3—60 CrossRef.

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